Endocrine Abstracts

Introduction: GH substitution in GH deficiency (GHD) must be subcutaneously administered daily. Recently, a new sustained release formulation of GH (LB03002) has been developed which has to be injected only once per week. As a sub-study to the double-blind, randomized, placebo-controlled, multicenter, phase-III-study we performed this prospective study to evaluate influences of the new GH formulation on metabolic parameters and the hormones leptin and ghrelin in adult patients...

Introduction: Patients with craniopharyngeoma often have disturbances of the hypothalamic–pituitary axis and serious comorbidities as obesity. We hypothesized, that the pattern of hormones regulating the nutritional status is worsened in adult patients with craniopharyngioma (CP) compared to adult patients with non-functioning pituitary adenoma (NFPA).Methods: We included 33 patients with CP (m=16, f=17, median age: 48 years (26–7...

Leptin and ghrelin are correlated to acute and chronic nutritional status. Elevated BMI and fat mass as well as food intake increase leptin levels whereas ghrelin levels are reduced. Ghrelin stimulates growth hormone (GH) secretion. The influence of GH on ghrelin is unclear. Since GH reduces fat mass and is dependent on nutritional status we performed this prospective cross sectional study in order to investigate any interaction between GH, ghrelin and leptin levels in active ...

Objective: The mechanisms underlying the well known glucagon-induced satiety effect are unclear. We showed earlier that glucagon induces a remarkable decrease in the orexigenic hormone: ghrelin. It was the aim of the present study to further evaluate the effect of glucagon on ghrelin secretion and the possible site of origin of this effect.Methods: We studied the endocrine and metabolic responses to intramuscular glucagon administration in 23 subjects (1...